Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

BACKGROUND Current methods for the detection and surveillance of bladder cancer (BCa)
are often invasive and/or possess suboptimal sensitivity and specificity, especially in early …

Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …

Telomeres are located at the ends of chromosomes and protect them from degradation.
Suppressing the activity of telomerase, a telomere‑synthesizing enzyme, and maintaining …

Bladder cancer (BC) ranks as the sixth most prevalent cancer in the world, with a steady rise
in its incidence and prevalence, and is accompanied by a high morbidity and mortality. BC is …

Background Identification of germline variation and somatic mutations is a major issue in
human genetics. However, due to the limitations of DNA sequencing technologies and …