Transcriptome‐wide interrogation of eukaryotic genomes has unveiled the pervasive nature
of RNA polymerase II transcription. Virtually, any DNA region with an accessible chromatin …

The system of long noncoding RNA (lncRNA)–mediated transcriptional interference that
represses fission yeast phosphate homoeostasis gene pho1 provides a sensitive readout of …

In eukaryotes, RNA polymerase II (Pol II) is responsible for the synthesis of all mRNAs and
myriads of short and long untranslated RNAs, whose fabrication involves close …

A substantial part of living cells activity involves transcription regulation. The RNA
polymerases responsible for this job need to know 'where/when'to start and stop in the …

Trypanosoma cruzi is the causative agent of Chagas disease, as well as a trypanosomatid
parasite with a complex biological cycle that requires precise mechanisms for regulating …

Summary The Nrd1-Nab3-Sen1 (NNS) complex carries out the transcription termination of
non-coding RNAs (ncRNAs) by RNA polymerase II (Pol II) in yeast, although the detailed …

Heterodimerization of RNA binding proteins Nrd1 and Nab3 is essential to communicate the
RNA recognition in the nascent transcript with the Nrd1 recognition of the Ser5 …

An asymmetry in cytosolic pH between mother and daughter cells was reported to underlie
cellular aging in the budding yeast Saccharomyces cerevisiae; however, the underlying …

How regulatory sequences control gene expression is fundamental for explaining
phenotypes in health and disease. The function of regulatory sequences must ultimately be …

Proteins that bind the nascent transcript exiting RNA polymerase II (RNAP II) can regulate
transcription elongation. The essential Saccharomyces cerevisiae hnRNP protein Hrp1 is …