Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex
Ras-related nuclear protein (Ran) is a member of the Ras superfamily of small guanosine
triphosphatases (GTPases) and a regulator of multiple cellular processes. In healthy cells …
triphosphatases (GTPases) and a regulator of multiple cellular processes. In healthy cells …
Molecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9
Imp9 is the primary importin for shuttling H2A-H2B from the cytoplasm to the nucleus. It
employs an unusual mechanism where the binding of RanGTP is insufficient to release H2A …
employs an unusual mechanism where the binding of RanGTP is insufficient to release H2A …
A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders
A Gonzalez, HJ Kim, BD Freibaum, HYJ Fung… - Structure, 2023 - cell.com
The HNRNPH2 proline-tyrosine nuclear localization signal (PY-NLS) is mutated in
HNRNPH2-related X-linked neurodevelopmental disorder, causing the normally nuclear …
HNRNPH2-related X-linked neurodevelopmental disorder, causing the normally nuclear …
Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus
Core histones, synthesized and processed in the cytoplasm, must be chaperoned as they
are transported into the nucleus for nucleosome assembly. The importin Kap114 transports …
are transported into the nucleus for nucleosome assembly. The importin Kap114 transports …