The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events
in humans with type 2 diabetes (T2D); however, the underlying mechanism remains unclear …

Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

It has long been observed that heart failure (HF) is associated with measures of systemic
inflammation. In recent years, there have been significant advancements in our …

Background Experimental and clinical data suggest that reducing inflammation without
affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory …

Obesity increases a number of cardiovascular disease (CVD) risk factors, but patients with
many types of CVD may have a better prognosis if classified as overweight or obese, a …

Obesity is associated with an increased risk of developing cardiovascular disease (CVD),
particularly heart failure (HF) and coronary heart disease (CHD). The mechanisms through …