Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed,
protein-serine/threonine kinases, which participate in signal transduction pathways that …

The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …

Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

Sequential activation of kinases within the mitogen-activated protein (MAP) kinase (MAPK)
cascades is a common, and evolutionary-conserved mechanism of signal transduction. Four …

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including
embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the …

Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase
cascades in their repertoire of signal transduction mechanisms. Recent advances in the …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …