Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …

Metabolic regulation has been recognized as a powerful principle guiding immune
responses. Inflammatory macrophages undergo extensive metabolic rewiring marked by the …

Summary N6-methyladenosine (m 6 A) is the most abundant modification on mRNA and is
implicated in critical roles in development, physiology, and disease. A major limitation has …

The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …

There is growing interest in the role of translational regulation in cellular homeostasis during
organismal development. Translation initiation is the rate-limiting step in mRNA translation …

Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully
produce haploid gametes. To date, only a handful of meiotic SUMO targets have been …

Highlights•Axons, much like dendrites, contain a remarkably diverse set of localized
transcripts.•Presynaptic translation allows for proteostasis in mature axons.•Presynaptic and …

Transcriptional and translational control are key determinants of gene expression, however,
to what extent these two processes can be collectively coordinated is still poorly understood …

It has recently become clear that ribosomes are much more heterogeneous than previously
thought, with diversity arising from rRNA sequence and modifications, ribosomal protein …