Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Healthy immune responses require efficient protection without excessive inflammation.
Recent discoveries on the degree of fucosylation of a human N-linked glycan at a conserved …

Carbohydrates (glycans, saccharides, sugars) are everywhere. In fact, glycan–protein
interactions are involved in many essential processes of life and disease. The …

Therapeutic monoclonal antibodies (mAbs) are largely based on the immunoglobulin G1
(IgG1) scaffold, and many elicit a cytotoxic cell-mediated response by binding Fc γ receptors …

Immunotherapy is revolutionizing health care, with the majority of high impact “drugs”
approved in the past decade falling into this category of therapy. Despite considerable …

The N-glycan moiety of IgG-Fc has a significant impact on multifaceted properties of
antibodies such as in their effector function, structure, and stability. Numerous studies have …

Most cells active in the immune system express receptors for antibodies which mediate a
variety of defensive mechanisms. These receptors interact with the Fc portion of the antibody …

Multiple sclerosis (MS) is an inflammatory autoimmune disorder affecting the central nervous
system (CNS), with unresolved aetiology. Previous studies have implicated N-glycosylation …

Therapeutic monoclonal antibodies (mAbs) are the fastest growing group of drugs with 11
new antibodies or antibody-drug conjugates approved by the Food and Drug Administration …

Antibodies engage Fc γ receptors (FcγRs) to elicit healing cellular immune responses
following binding to a target antigen. Fc γ receptor IIIa/CD16a triggers natural killer cells to …