Accurate repair of DNA double-strand breaks is essential to life. Indeed, defective DNA
double-strand break repair can lead to toxicity and large scale sequence rearrangements …

Poly (ADP-ribose) polymerase (PARP) is responsible for post-translational modification of
proteins in the response to numerous endogenous and environmental genotoxic agents …

If replication forks are perturbed, a multifaceted response including several DNA repair and
cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show …

Messenger RNA levels were measured in actively dividing fibroblasts isolated from young,
middle-age, and old-age humans and humans with progeria, a rare genetic disorder …

Cells with non‐functional poly (ADP‐ribose) polymerase (PARP‐1) show increased levels of
sister chromatid exchange, suggesting a hyper recombination phenotype in these cells. To …

Homologous recombination (HR) is essential for cellular survival in mammals. In this review,
the substrates for HR, the pathways of repair, and their end products (ie sister chromatid …

Abstract Poly (ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear enzyme involved
in DNA repair. The therapeutic efficacy of drugs that inhibit PARP-1 in various disorders …

For cells on the path to carcinogenesis, the key to unlimited growth potential lies in
overcoming the steady loss of telomeric sequence commonly referred to as the 'end …

Micronutrients, including minerals and vitamins, are indispensable to DNA metabolic
pathways and thus are as important for life as macronutrients. Without the proper nutrients …

DNA strand breaks arise continuously in cells and can lead to chromosome rearrangements
and genome instability or cell death. The commonest DNA breaks are DNA single-strand …