Catalytic cross-coupling reactions have had a profound impact on the synthesis of
pharmaceuticals, biologically active natural products, and materials. 1 Such reactions …

Efficient and reliable amplification of chirality has borne its greatest fruit with transition metal-
catalyzed reactions since enantiocontrol may often be imposed by replacing an achiral or …

An important first step in making organic reactions more environmentally benign by design
requires processes that are, to a first approximation, simple additions with anything else …

Metal-catalyzed reactions have made a great contribution to the recent growth of organic
synthesis, and a variety of synthetic methods have been reported using mainly group 8 …

In this area, transition metal catalyzed reactions have proven highly selective and atom
economical. However, outside of ruthenium-catalyzed ring closing metathesis, 1 the …

The transformation of the hydroxy group into the corresponding carbonyl is one of the most
frequently used reactions in organic synthesis. Traditionally, stoichiometric and even over …

The synthesis of enantiomerically pure compounds is an extremely important undertaking
and a formida-ble challenge to thesynthetic chemist. 1 The importance of enantiomerically …

We have reported in 1965 that n-allylpalfadium chloride (1) reacts with C-nucleophiles such
as malonates, acetoacetates, and enamines (Eq. l), and shown that the reaction offers a new …

In 1965 we reported that (ir-allyl) palladium chloride reacts with carbonucleophiles such as
malonates, acetoacetates, and enamines, thereby offering a new method for carbon-carbon …

An efficient procedure for the oxidation of primary and secondary allylic and benzylic
alcohols to aldehydes and ketones, respectively, has been achieved using catalytic Pd …