Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …

γδ T cells in tissue physiology and surveillance

JC Ribot, N Lopes, B Silva-Santos - Nature Reviews Immunology, 2021 - nature.com
Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

IL-17 and IL-17-producing cells in protection versus pathology

KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

Mucosal immune responses to infection and vaccination in the respiratory tract

RC Mettelman, EK Allen, PG Thomas - Immunity, 2022 - cell.com
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors

C Harmon, A Zaborowski, H Moore, P St. Louis… - Nature cancer, 2023 - nature.com
Abstract γδ T cells are important tissue-resident, innate T cells that are critical for tissue
homeostasis. γδ cells are associated with positive prognosis in most tumors; however, little …

Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology

RC Mettelman, A Souquette, LA Van de Velde… - Nature …, 2023 - nature.com
Evidence suggests that innate and adaptive cellular responses mediate resistance to the
influenza virus and confer protection after vaccination. However, few studies have resolved …

Early-life imprinting of unconventional T cells and tissue homeostasis

MG Constantinides, Y Belkaid - Science, 2021 - science.org
BACKGROUND In addition to providing antimicrobial immunity, the immune system governs
numerous aspects of host physiology, in part through the coordinated action of tissue …

PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A–producing γδ T cells

SC Edwards, A Hedley, WHM Hoevenaar… - Journal of Experimental …, 2023 - rupress.org
IL-17A–producing γδ T cells in mice consist primarily of Vγ6+ tissue-resident cells and Vγ4+
circulating cells. How these γδ T cell subsets are regulated during homeostasis and cancer …

Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung

LD Faustino, JW Griffith, RA Rahimi, K Nepal… - Nature …, 2020 - nature.com
Abstract Foxp3+ regulatory T (Treg) cells expressing the interleukin (IL)-33 receptor ST2
mediate tissue repair in response to IL-33. Whether Treg cells also respond to the alarmin IL …

Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

EL Goldberg, I Shchukina, JL Asher, S Sidorov… - Nature …, 2020 - nature.com
Ketone bodies are essential alternative fuels that allow humans to survive periods of
glucose scarcity induced by starvation and prolonged exercise. A widely used ketogenic diet …