Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …

Complement activation generates the core effector protein C5a, a potent immune molecule
that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 (C5aR, CD88) …

The aberrant activation of complement system in several kidney diseases suggests that this
pillar of innate immunity has a critical role in the pathophysiology of renal damage of …

The current immunosuppressive protocols used in transplant recipients have improved short-
term outcomes, but long-term allograft failure remains an important clinical problem. Greater …

Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function
and increased mortality post-liver transplantation. The mechanism of IRI involves multiple …

Macrophages play an important role in renal injury and repair after acute kidney injury (AKI)
and the subsequent chronic kidney disease (CKD) that often results. However, as …

Introduction Renal ischemia/reperfusion injury (IRI) remains one of the most diseases in
clinic. The purpose of this study was to investigate the potential role and mechanism of …

C5a is a potent inflammatory mediator that binds C5aR1 and C5aR2. Although pathogenic
roles of the C5a/C5aR1 axis in inflammatory disorders are well documented, the roles for the …

Abstract Objectives The role of Paeoniflorin on hepatic fibrosis and the specific mechanisms
has not yet been elucidated. Therefore, we explored whether Paeoniflorin exerted protective …