Mass spectrometry of nucleic acid noncovalent complexes

E Largy, A Konig, A Ghosh, D Ghosh… - Chemical …, 2021 - ACS Publications
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules

A Granzhan, N Kotera… - Chemical Society Reviews, 2014 - pubs.rsc.org
Mismatched (non-Watson–Crick) base pairs represent the most common type of DNA
damage, as they are permanently formed in living cells due to erroneous insertion, deletion …

DNA-hosted copper nanoclusters for fluorescent identification of single nucleotide polymorphisms

X Jia, J Li, L Han, J Ren, X Yang, E Wang - Acs Nano, 2012 - ACS Publications
Metal nanoclusters have received considerable interest due to their unique properties and
potential applications in numerous fields. Particularly, newly emerging Cu nanoclusters offer …

Identifying G-quadruplex-DNA-disrupting small molecules

J Mitteaux, P Lejault, F Wojciechowski… - Journal of the …, 2021 - ACS Publications
The quest for small molecules that strongly bind to G-quadruplex-DNA (G4), so-called G4
ligands, has invigorated the G4 research field from its very inception. Massive efforts have …

Thermodynamic and structural study of phenanthroline derivative ruthenium complex/DNA interactions: probing partial intercalation and binding properties

E Grueso, G López-Pérez, M Castellano… - Journal of Inorganic …, 2012 - Elsevier
The binding of [Ru (PDTA-H2)(phen)] Cl (PDTA= propylene-1, 2-diaminetetra-acetic acid;
phen= 1, 10 phenanthroline) with ctDNA (= calf thymus DNA) has been investigated through …

NMR determination of the 2: 1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

T Yamada, K Furuita, S Sakurabayashi… - Nucleic Acids …, 2022 - academic.oup.com
Trinucleotide repeat (TNR) diseases are caused by the aberrant expansion of CXG (X= C, A,
G and T) sequences in genomes. We have reported two small molecules binding to TNR …

Ratiometric detection of ATP by fluorescent cyclophanes with bellows‐type sensing mechanism

AM Agafontsev, TA Shumilova… - … A European Journal, 2020 - Wiley Online Library
Pyrene‐based cyclophanes have been synthesized with the aim to realize a bellows‐type
sensing mechanism for the ratiometric detection of nucleotide concentrations in a buffered …

One Ring to Bind Them All”—Part I: The Efficiency of the Macrocyclic Scaffold for G‐Quadruplex DNA Recognition

D Monchaud, A Granzhan, N Saettel… - Journal of Nucleic …, 2010 - Wiley Online Library
Macrocyclic scaffolds are particularly attractive for designing selective G‐quadruplex ligands
essentially because, on one hand, they show a poor affinity for the “standard” B‐DNA …

FederatedCloudSim: a SLA-aware federated cloud simulation framework

A Kohne, M Spohr, L Nagel, O Spinczyk - Proceedings of the 2nd …, 2014 - dl.acm.org
Recent developments show that the standardization of cloud service descriptions and
exchange leads the way for the rise of cloud federations. In these federations CSPs (cloud …

Binding studies of the anti‐retroviral drug, efavirenz to calf thymus DNA using spectroscopic and voltammetric techniques

M Sadeghi, M Bayat, S Cheraghi, K Yari… - …, 2016 - Wiley Online Library
Interactions between efavirenz (EFZ) with calf thymus DNA (CT‐DNA) were investigated in
vitro under stimulated physiological conditions using multispectroscopic techniques, cyclic …