The biology and functional importance of MAIT cells
DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
Innate lymphoid cells and innate-like T cells in cancer—at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …
many cancers, yet only a subset of patients benefit from these approaches. A better …
MAIT cells are activated during human viral infections
B Van Wilgenburg, I Scherwitzl, EC Hutchinson… - Nature …, 2016 - nature.com
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions
T Leng, HD Akther, CP Hackstein, K Powell, T King… - Cell reports, 2019 - cell.com
MAIT cells are an unconventional T cell population that can be activated through both TCR-
dependent and TCR-independent mechanisms. Here, we examined the impact of …
dependent and TCR-independent mechanisms. Here, we examined the impact of …
TCR-or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses
R Lamichhane, M Schneider, SM de la Harpe… - Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …
MAIT cells in health and disease
NM Provine, P Klenerman - Annual review of immunology, 2020 - annualreviews.org
Mucosal-associated invariant T (MAIT) cells have been attracting increasing attention over
the last few years as a potent unconventional T cell subset. Three factors largely account for …
the last few years as a potent unconventional T cell subset. Three factors largely account for …
MAIT cell activation and functions
TSC Hinks, XW Zhang - Frontiers in immunology, 2020 - frontiersin.org
Mucosal associated invariant T (MAIT) cells are striking in their abundance and their strict
conservation across 150 million years of mammalian evolution, implying they must fulfill …
conservation across 150 million years of mammalian evolution, implying they must fulfill …
[HTML][HTML] MAIT cells, guardians of skin and mucosa?
I Nel, L Bertrand, A Toubal, A Lehuen - Mucosal immunology, 2021 - Elsevier
Abstract Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …
T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis …
Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation
Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes known to elicit
potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory …
potent immunity to a broad range of bacteria, mainly via the rapid production of inflammatory …
MAIT cells: new guardians of the liver
A Kurioka, LJ Walker, P Klenerman… - Clinical & translational …, 2016 - Wiley Online Library
The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …