Evolution by gene loss
R Albalat, C Cañestro - Nature Reviews Genetics, 2016 - nature.com
The recent increase in genomic data is revealing an unexpected perspective of gene loss as
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …
Recent advances in metabolic engineering of Saccharomyces cerevisiae: new tools and their applications
Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Promises and pitfalls of untargeted metabolomics
I Gertsman, BA Barshop - Journal of inherited metabolic disease, 2018 - Springer
Metabolomics is one of the newer omics fields, and has enabled researchers to complement
genomic and protein level analysis of disease with both semi-quantitative and quantitative …
genomic and protein level analysis of disease with both semi-quantitative and quantitative …
Regulation of G 6 PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress
Abstract Glucose‐6‐phosphate dehydrogenase (G6 PD) is a key enzyme in the pentose
phosphate pathway (PPP) and plays an essential role in the oxidative stress response by …
phosphate pathway (PPP) and plays an essential role in the oxidative stress response by …
Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals
Industrial bio-processes for fine chemical production are increasingly relying on cell
factories developed through metabolic engineering and synthetic biology. The use of high …
factories developed through metabolic engineering and synthetic biology. The use of high …
13C-based metabolic flux analysis
Stable isotope, and in particular 13C-based flux analysis, is the exclusive approach to
experimentally quantify the integrated responses of metabolic networks. Here we describe a …
experimentally quantify the integrated responses of metabolic networks. Here we describe a …
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
To which extent can optimality principles describe the operation of metabolic networks? By
explicitly considering experimental errors and in silico alternate optima in flux balance …
explicitly considering experimental errors and in silico alternate optima in flux balance …
Metabolic networks in motion: 13C‐based flux analysis
U Sauer - Molecular systems biology, 2006 - embopress.org
Many properties of complex networks cannot be understood from monitoring the
components—not even when comprehensively monitoring all protein or metabolite …
components—not even when comprehensively monitoring all protein or metabolite …
Evolutionary convergence of pathway-specific enzyme expression stoichiometry
Coexpression of proteins in response to pathway-inducing signals is the founding paradigm
of gene regulation. However, it remains unexplored whether the relative abundance of co …
of gene regulation. However, it remains unexplored whether the relative abundance of co …