Parkinson's disease (PD) is a common neurodegenerative disease developed due to the
degeneration of dopaminergic neurons in the substantia nigra. There is no single effective …

Introduction: Metformin is currently first line therapy for type 2 diabetes (T2D). The
mechanism of action of metformin involves activation of AMP-activated protein kinase …

Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins,
lipids and damaged organelles to the lysosomes for degradation and elimination. The …

In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …

Epilepsy is a chronic neurological disease characterized by recurrent seizures. Epilepsy is
observed as a well‐controlled disease by anti‐epileptic agents (AEAs) in about 69 …

Background Metformin is a drug commonly used in individuals with type 2 diabetes, obesity,
and impaired glucose tolerance. It has a strong safety profile in both children and adults …

Fragile X syndrome (FXS) is the most frequent inherited form of intellectual disability and
autism spectrum disorder. Loss of the fragile X mental retardation protein, FMRP, engenders …

Patients with diabetes and epilepsy are more prone to cognitive impairment, dementia, and
even Alzheimer's disease. Diabetes-induced inflammatory process is one of the main …

Background Available anti-seizure medications (ASMs) target the symptomatology of the
disease rather than any significant disease/epileptogenesis modifying actions. There are …

The present study was designed to examine the possible neuroprotective and antiepileptic
effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and …