A decade of advances in transposon-insertion sequencing
It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS)
methods, which combine genome-wide transposon mutagenesis with high-throughput …
methods, which combine genome-wide transposon mutagenesis with high-throughput …
[HTML][HTML] The vulnerable versatility of Salmonella antibiotic persisters during infection
Tolerance and persistence are superficially similar phenomena by which bacteria survive
bactericidal antibiotics. It is assumed that the same physiology underlies survival of …
bactericidal antibiotics. It is assumed that the same physiology underlies survival of …
Shedding light on bacteria–host interactions with the aid of TnSeq approaches
M Torres, S Paszti, L Eberl - Mbio, 2024 - Am Soc Microbiol
Bacteria are highly adaptable and grow in diverse niches, where they often interact with
eukaryotic organisms. These interactions with different hosts span the entire spectrum from …
eukaryotic organisms. These interactions with different hosts span the entire spectrum from …
Structure, biosynthesis and regulation of the T1 antigen, a phase-variable surface polysaccharide conserved in many Salmonella serovars
SD Kelly, MJ Allas, LD Goodridge, TL Lowary… - Nature …, 2024 - nature.com
The bacterial genus Salmonella includes diverse isolates with multiple variations in the
structure of the main polysaccharide component (O antigen) of membrane …
structure of the main polysaccharide component (O antigen) of membrane …
Genome-wide analysis of fitness-factors in uropathogenic Escherichia coli during growth in laboratory media and during urinary tract infections
V García, RB Grønnemose… - Microbial …, 2021 - microbiologyresearch.org
Uropathogenic Escherichia coli (UPEC) UTI89 is a well-characterized strain, which has
mainly been used to study UPEC virulence during urinary tract infection (UTI). However, little …
mainly been used to study UPEC virulence during urinary tract infection (UTI). However, little …
High-throughput fitness experiments reveal specific vulnerabilities of human-adapted Salmonella during stress and infection
Salmonella enterica is comprised of genetically distinct 'serovars' that together provide an
intriguing model for exploring the genetic basis of pathogen evolution. Although the …
intriguing model for exploring the genetic basis of pathogen evolution. Although the …
Genome-wide fitness analysis of Salmonella enterica reveals aroA mutants are attenuated due to iron restriction in vitro
Salmonella enterica is a globally disseminated pathogen that is the cause of over 100
million infections per year. The resulting diseases are dependent upon host susceptibility …
million infections per year. The resulting diseases are dependent upon host susceptibility …
Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa
The various sub-species of Salmonella enterica cause a range of disease in human hosts.
The human-adapted Salmonella enterica serovar Typhi enters the gastrointestinal tract and …
The human-adapted Salmonella enterica serovar Typhi enters the gastrointestinal tract and …
A global data-driven census of Salmonella small proteins and their potential functions in bacterial virulence
E Venturini, SL Svensson, S Maaß, R Gelhausen… - …, 2020 - academic.oup.com
Small proteins are an emerging class of gene products with diverse roles in bacterial
physiology. However, a full understanding of their importance has been hampered by …
physiology. However, a full understanding of their importance has been hampered by …
Gene essentiality profiling reveals a novel determinant of stresses preventing protein aggregation in Salmonella
Z Wang, S Zhu, C Li, L Lyu, J Yu, D Wang… - Emerging Microbes & …, 2022 - Taylor & Francis
Adaptation to various stresses during infection is important for Salmonella Typhimurium
virulence, while the fitness determinants under infection-relevant stress conditions remain …
virulence, while the fitness determinants under infection-relevant stress conditions remain …