The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a
balance in internal environment (temperature, mood, and immune system) and energy input …

The pharmacological importance of cannabinoids has been in study for several years.
Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant,(b) …

The endocannabinoid system is implicated in a variety of physiological and pathological
conditions (inflammation, immunomodulation, analgesia, cancer and others). The main …

Cannabis has the potential to modulate some of the most common and debilitating
symptoms of cancer and its treatments, including nausea and vomiting, loss of appetite, and …

Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between
osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) …

The misuse of prescription opiates is on the rise with combination therapies (eg
acetaminophen or NSAIDs) resulting in severe liver and kidney damage. In recent years …

To date, preclinical data has demonstrated evidence to suggest promising potential for
cancer pain and the urgent need to translate this into clinical practice. Unfortunately, due to …

The global burden of cancer pain is enormous and opioids, despite their side effects, remain
the primary therapeutic approach. The cause of cancer pain is unknown. Mechanisms …

The endocannabinoid system has been postulated to help restrict cancer progression and
maintain osteoblastic function during bone metastasis. Herein, the effects of cannabinoid …

The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well
established. However, the side-effect profile of CB1 receptor ligands has necessitated the …