Novel insights into atopic dermatitis
Recent research into the pathophysiology and treatment of atopic dermatitis (AD) has shown
notable progress. An increasing number of aspects of the immune system are being …
notable progress. An increasing number of aspects of the immune system are being …
[HTML][HTML] Mast cell-mediated immune regulation in health and disease
KN Dileepan, VV Raveendran, R Sharma… - Frontiers in …, 2023 - frontiersin.org
Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …
[HTML][HTML] Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients
JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu… - Signal transduction and …, 2021 - nature.com
Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …
[HTML][HTML] The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells
C Leoni, M Bataclan, T Ito-Kureha… - Nature …, 2023 - nature.com
Mast cells are central players in allergy and asthma, and their dysregulated responses lead
to reduced quality of life and life-threatening conditions such as anaphylaxis. The RNA …
to reduced quality of life and life-threatening conditions such as anaphylaxis. The RNA …
[HTML][HTML] Mast cells in the skin: defenders of integrity or offenders in inflammation?
Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions
that may even culminate in life-threatening anaphylactic shock syndromes. However …
that may even culminate in life-threatening anaphylactic shock syndromes. However …
Tralokinumab therapy for moderate‐to‐severe atopic dermatitis: Clinical outcomes with targeted IL‐13 inhibition
Atopic dermatitis (AD) is a chronic, inflammatory, intensely pruritic skin disorder associated
with significant patient burden. Interleukin (IL)‐13 is a cytokine that acts as a driver of …
with significant patient burden. Interleukin (IL)‐13 is a cytokine that acts as a driver of …
[HTML][HTML] Two sides of the coin: Mast cells as a key regulator of allergy and acute/chronic inflammation
Z Zhang, Y Kurashima - Cells, 2021 - mdpi.com
It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a
quick response to the various stimulants, including—but not limited to—allergens, pathogen …
quick response to the various stimulants, including—but not limited to—allergens, pathogen …
[HTML][HTML] Role of Innate Immunity in Allergic Contact Dermatitis: An Update
HL Yamaguchi, Y Yamaguchi, E Peeva - International Journal of …, 2023 - mdpi.com
Our understanding of allergic contact dermatitis mechanisms has progressed over the past
decade. Innate immune cells that are involved in the pathogenesis of allergic contact …
decade. Innate immune cells that are involved in the pathogenesis of allergic contact …
Unexpected connections of the IL-23/IL-17 and IL-4/IL-13 cytokine axes in inflammatory arthritis and enthesitis
Abstract The IL-23/IL-17 cytokine axis is related to spondyloarthropathy (SpA) pattern
diseases that target the skin, eye, gut and joints. These share overlapping target tissues with …
diseases that target the skin, eye, gut and joints. These share overlapping target tissues with …
[HTML][HTML] Understanding the development of Th2 cell-driven allergic airway disease in early life
B León - Frontiers in Allergy, 2023 - frontiersin.org
Allergic diseases, including atopic dermatitis, allergic rhinitis, asthma, and food allergy, are
caused by abnormal responses to relatively harmless foreign proteins called allergens …
caused by abnormal responses to relatively harmless foreign proteins called allergens …