Novel insights into atopic dermatitis

CF Schuler IV, AC Billi, E Maverakis, LC Tsoi… - Journal of Allergy and …, 2023 - Elsevier
Recent research into the pathophysiology and treatment of atopic dermatitis (AD) has shown
notable progress. An increasing number of aspects of the immune system are being …

[HTML][HTML] Mast cell-mediated immune regulation in health and disease

KN Dileepan, VV Raveendran, R Sharma… - Frontiers in …, 2023 - frontiersin.org
Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

[HTML][HTML] Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

JL Zhang, YH Li, LL Wang, HQ Liu, SY Lu… - Signal transduction and …, 2021 - nature.com
Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase
(RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into …

[HTML][HTML] The mRNA methyltransferase Mettl3 modulates cytokine mRNA stability and limits functional responses in mast cells

C Leoni, M Bataclan, T Ito-Kureha… - Nature …, 2023 - nature.com
Mast cells are central players in allergy and asthma, and their dysregulated responses lead
to reduced quality of life and life-threatening conditions such as anaphylaxis. The RNA …

[HTML][HTML] Mast cells in the skin: defenders of integrity or offenders in inflammation?

M Voss, J Kotrba, E Gaffal… - International Journal of …, 2021 - mdpi.com
Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions
that may even culminate in life-threatening anaphylactic shock syndromes. However …

Tralokinumab therapy for moderate‐to‐severe atopic dermatitis: Clinical outcomes with targeted IL‐13 inhibition

EL Simpson, E Guttman‐Yassky, LF Eichenfield… - Allergy, 2023 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, inflammatory, intensely pruritic skin disorder associated
with significant patient burden. Interleukin (IL)‐13 is a cytokine that acts as a driver of …

[HTML][HTML] Two sides of the coin: Mast cells as a key regulator of allergy and acute/chronic inflammation

Z Zhang, Y Kurashima - Cells, 2021 - mdpi.com
It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a
quick response to the various stimulants, including—but not limited to—allergens, pathogen …

[HTML][HTML] Role of Innate Immunity in Allergic Contact Dermatitis: An Update

HL Yamaguchi, Y Yamaguchi, E Peeva - International Journal of …, 2023 - mdpi.com
Our understanding of allergic contact dermatitis mechanisms has progressed over the past
decade. Innate immune cells that are involved in the pathogenesis of allergic contact …

Unexpected connections of the IL-23/IL-17 and IL-4/IL-13 cytokine axes in inflammatory arthritis and enthesitis

C Bridgewood, D Newton, N Bragazzi… - Seminars in …, 2021 - Elsevier
Abstract The IL-23/IL-17 cytokine axis is related to spondyloarthropathy (SpA) pattern
diseases that target the skin, eye, gut and joints. These share overlapping target tissues with …

[HTML][HTML] Understanding the development of Th2 cell-driven allergic airway disease in early life

B León - Frontiers in Allergy, 2023 - frontiersin.org
Allergic diseases, including atopic dermatitis, allergic rhinitis, asthma, and food allergy, are
caused by abnormal responses to relatively harmless foreign proteins called allergens …