Gene delivery by lipoplexes and polyplexes

CT de Ilarduya, Y Sun, N Düzgüneş - European journal of pharmaceutical …, 2010 - Elsevier
Gene therapy has emerged as a promising approach for the treatment or prevention of
acquired and genetic diseases. At the present time, major somatic gene transfer approaches …

Block copolymer micelles: preparation, characterization and application in drug delivery

G Gaucher, MH Dufresne, VP Sant, N Kang… - Journal of controlled …, 2005 - Elsevier
Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or
oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic …

Polyethylenimine-based non-viral gene delivery systems

U Lungwitz, M Breunig, T Blunk, A Göpferich - European Journal of …, 2005 - Elsevier
Gene therapy has become a promising strategy for the treatment of many inheritable or
acquired diseases that are currently considered incurable. Non-viral vectors have attracted …

Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery

N Nishiyama, K Kataoka - Pharmacology & therapeutics, 2006 - Elsevier
Polymeric micelles, self-assemblies of block copolymers, are promising nanocarrier systems
for drug and gene delivery. Until now, several micellar formulations of antitumor drugs have …

Current status of polymeric gene delivery systems

TG Park, JH Jeong, SW Kim - Advanced drug delivery reviews, 2006 - Elsevier
Gene therapy provides great opportunities for treating diseases from genetic disorders,
infections and cancer. To achieve successful gene therapy, development of proper gene …

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

M Morille, C Passirani, A Vonarbourg, A Clavreul… - Biomaterials, 2008 - Elsevier
Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its
potential role in the treatment of acquired diseases such as cancer is now widely …

Recent advances in rational gene transfer vector design based on poly (ethylene imine) and its derivatives

M Neu, D Fischer, T Kissel - The Journal of Gene Medicine: A …, 2005 - Wiley Online Library
The continually increasing wealth of knowledge about the role of genes involved in acquired
or hereditary diseases renders the delivery of regulatory genes or nucleic acids into affected …

Polymer architecture and drug delivery

LY Qiu, YH Bae - Pharmaceutical research, 2006 - Springer
Polymers occupy a major portion of materials used for controlled release formulations and
drug-targeting systems because this class of materials presents seemingly endless diversity …

Self-assembling materials for therapeutic delivery

MC Branco, JP Schneider - Acta biomaterialia, 2009 - Elsevier
A growing number of medications must be administered through parenteral delivery, ie,
intravenous, intramuscular, or subcutaneous injection, to ensure effectiveness of the …

Targeting nucleic acid-based therapeutics to tumors: Challenges and strategies for polyplexes

VC Vetter, E Wagner - Journal of Controlled Release, 2022 - Elsevier
The current medical reality of cancer gene therapy is reflected by more than ten approved
products on the global market, including oncolytic and other viral vectors and CAR T-cells as …