Validating genome-wide CRISPR-Cas9 function improves screening in the oleaginous yeast Yarrowia lipolytica
C Schwartz, JF Cheng, R Evans, CA Schwartz… - Metabolic …, 2019 - Elsevier
Genome-wide mutational screens are central to understanding the genetic underpinnings of
evolved and engineered phenotypes. The widespread adoption of CRISPR-Cas9 genome …
evolved and engineered phenotypes. The widespread adoption of CRISPR-Cas9 genome …
Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide- and strain-dependent features influencing antimicrobial …
CRISPR-Cas systems can be utilized as programmable-spectrum antimicrobials to combat
bacterial infections. However, how CRISPR nucleases perform as antimicrobials across …
bacterial infections. However, how CRISPR nucleases perform as antimicrobials across …
ACE: a probabilistic model for characterizing gene-level essentiality in CRISPR screens
High-throughput CRISPR-Cas9 knockout screens are widely used to evaluate gene
essentiality in cancer research. Here we introduce a probabilistic modeling framework …
essentiality in cancer research. Here we introduce a probabilistic modeling framework …