Exosome-based vaccines: history, current state, and clinical trials

P Santos, F Almeida - Frontiers in immunology, 2021 - frontiersin.org
Extracellular vesicles (EVs) are released by most cell types as part of an intracellular
communication system in crucial processes such as inflammation, cell proliferation, and …

Tumor-derived extracellular vesicles: The metastatic organotropism drivers

J Rezaie, M Ahmadi, R Ravanbakhsh, B Mojarad… - Life Sciences, 2022 - Elsevier
The continuous growing, spreading, and metastasis of tumor cells depend on intercellular
communication within cells resident in a tissue environment. Such communication is …

Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses

B Zuo, Y Zhang, K Zhao, L Wu, H Qi, R Yang… - Journal of hematology & …, 2022 - Springer
Background Personalized immunotherapy utilizing cancer vaccines tailored to the tumors of
individual patients holds promise for tumors with high genetic heterogeneity, potentially …

[HTML][HTML] Extracellular vesicles: emerging tools as therapeutic agent carriers

S Liu, X Wu, S Chandra, C Lyon, B Ning, J Fan… - … Pharmaceutica Sinica B, 2022 - Elsevier
Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …

[HTML][HTML] Small extracellular vesicles in cancer

K Abhange, A Makler, Y Wen, N Ramnauth, W Mao… - Bioactive Materials, 2021 - Elsevier
Extracellular vesicles (EV) are lipid-bilayer enclosed vesicles in submicron size that are
released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids …

Biosynthetic dendritic cell-exocytosed aggregation-induced emission nanoparticles for synergistic photodynamic immunotherapy

H Cao, H Gao, L Wang, Y Cheng, X Wu, X Shen… - ACS …, 2022 - ACS Publications
Dendritic cell (DC)-derived small extracellular vesicles (DEVs) are recognized as a highly
promising alternative to DC vaccines; however, the clinical testing of DEV-based …

Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities

A Vahabi, J Rezaie, M Hassanpour, Y Panahi… - Biochemical …, 2022 - Elsevier
Recently, circular RNAs (circRNAs) have appealed to a growing interest due to their
abundant expression and potential functions in cancer development. The most biological …

Emerging role of cancer-associated fibroblasts-derived exosomes in tumorigenesis

L Peng, D Wang, Y Han, T Huang, X He… - Frontiers in …, 2022 - frontiersin.org
Cancer-associated fibroblasts (CAFs) are the most important component of the stromal cell
population in the tumor microenvironment and play an irreplaceable role in oncogenesis …

Protein corona and exosomes: new challenges and prospects

M Heidarzadeh, A Zarebkohan, R Rahbarghazi… - Cell Communication and …, 2023 - Springer
Recent advances in extracellular vesicle (EVs) detection and isolation methods have led to
the development of novel therapeutic modalities. Among different types of EVs, exosomes …

[HTML][HTML] Recent progress of dendritic cell-derived exosomes (Dex) as an anti-cancer nanovaccine

J Xia, Y Miao, X Wang, X Huang, J Dai - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Although cancer vaccines such as dendritic cell (DC) vaccines and peptide vaccines have
become appealing and attractive anticancer immunotherapy options in recent decades …