Tuberculous meningitis: progress and remaining questions

J Huynh, J Donovan, NH Phu, HDT Nghia… - The Lancet …, 2022 - thelancet.com
Tuberculous meningitis is a devastating brain infection that is caused by Mycobacterium
tuberculosis and is notoriously difficult to diagnose and treat. New technologies …

Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches

CM Manyelo, RS Solomons, G Walzl… - Journal of clinical …, 2021 - Am Soc Microbiol
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …

Intensified antituberculosis therapy in adults with tuberculous meningitis

AD Heemskerk, ND Bang, NTH Mai… - … England Journal of …, 2016 - Mass Medical Soc
Background Tuberculous meningitis is often lethal. Early antituberculosis treatment and
adjunctive treatment with glucocorticoids improve survival, but nearly one third of patients …

The global burden of tuberculous meningitis in adults: a modelling study

PJ Dodd, M Osman, FV Cresswell… - PLOS Global Public …, 2021 - journals.plos.org
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis. The incidence and
mortality of TBM is unknown due to diagnostic challenges and limited disaggregated …

Tuberculosis IRIS: pathogenesis, presentation, and management across the spectrum of disease

CM Quinn, V Poplin, J Kasibante, K Yuquimpo… - Life, 2020 - mdpi.com
Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV
coinfection, is often complicated by the TB-associated immune reconstitution inflammatory …

[HTML][HTML] Challenges in the diagnosis of tuberculous meningitis

CF Palacios, PG Saleeb - Journal of clinical tuberculosis and other …, 2020 - Elsevier
Tuberculosis (TB) continues to pose a significant public health problem. Tuberculous
meningitis (TBM) is the most severe form of extra-pulmonary TB. TBM carries a high mortality …

Tuberculous granuloma: emerging insights from proteomics and metabolomics

AR Sholeye, AA Williams, DT Loots… - Frontiers in …, 2022 - frontiersin.org
Mycobacterium tuberculosis infection, which claims hundreds of thousands of lives each
year, is typically characterized by the formation of tuberculous granulomas—the …

Treatment and outcome in children with tuberculous meningitis: a multicenter pediatric tuberculosis network European trials group study

S Thee, R Basu Roy… - Clinical Infectious …, 2022 - academic.oup.com
Background Currently, data on treatment, outcome, and prognostic factors in children with
tuberculous meningitis (TBM) in Europe are limited. To date, most existing data on TBM …

Central nervous system tuberculosis

S Dian, AR Ganiem… - Current opinion in …, 2021 - journals.lww.com
Recent studies in the field of CNS-TB have largely focussed on TB meningitis. The outcome
may improve by optimizing treatment dosing. This needs to be confirmed in clinical trials …

Central inflammatory cytokines in tuberculous meningitis: a systematic review and meta-analysis

A Saghazadeh, N Rezaei - Journal of Interferon & Cytokine …, 2022 - liebertpub.com
No formal agreement exists regarding central inflammatory cytokine aberrations in
tuberculosis (TB). We undertook a systematic review and meta-analysis of studies …