1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

Purpose This work aims to identify differential metabolites and predicting molecular
subtypes of breast cancer (BC). Methods Plasma samples were collected from 96 BC …

Dysregulation of fatty acid metabolism and de novo lipogenesis is a key driver of several
cancer types through highly unsaturated fatty acid (HUFA) signaling precursors such as …

Arachidonate lipoxygenases (ALOX) have been implicated in playing a critical role in
tumorigenesis, development, and metastasis. We previously reported that ALOX12 is …

Introduction: Phospholipases A2 have been implicated in various pathological conditions,
such as rheumatoid arthritis, cardiovascular diseases, neurological disorders and cancer …

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is essential for
maintaining normal function of the adult heart and is known to play an important role in …

Arachidonic acid (AA) is a phospholipase A2 metabolite that has been reported to mediate a
plethora of cellular mechanisms involved in healthy and pathological states such as platelet …

Liver cancer has variable incidence worldwide and high mortality. Histologically, the most
common subtype of liver cancer is hepatocellular carcinoma (HCC). Approximately 30-40 …

We previously demonstrated that ceramide 1-phosphate (C1P) is mitogenic for fibroblasts
and macrophages. However, the mechanisms involved in this action were only partially …