Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

B Sun, L Wu, Y Wu, C Zhang, L Qin… - Frontiers in …, 2020 - frontiersin.org
Centella asiatica (also known as Centella asiatica (L.) Urb. or Gotu kola) is a traditional
Chinese medicine with extensive medicinal value, which is commonly used in Southeast …

Parkinson disease and the immune system—associations, mechanisms and therapeutics

EK Tan, YX Chao, A West, LL Chan, W Poewe… - Nature Reviews …, 2020 - nature.com
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …

The role of zinc, copper, manganese and iron in neurodegenerative diseases

L Mezzaroba, DF Alfieri, ANC Simão, EMV Reiche - Neurotoxicology, 2019 - Elsevier
Metals are involved in different pathophysiological mechanisms associated with
neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's …

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

F Pellati, V Borgonetti, V Brighenti… - BioMed research …, 2018 - Wiley Online Library
In the last decades, a lot of attention has been paid to the compounds present in medicinal
Cannabis sativa L., such as Δ9‐tetrahydrocannabinol (Δ9‐THC) and cannabidiol (CBD) …

SIRT1 pathway in Parkinson's disease: a faraway snapshot but so close

GES Batiha, HM Al-Kuraishy, AI Al-Gareeb… - …, 2023 - Springer
Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

Neuroprotective activities of curcumin in Parkinson's disease: a review of the literature

EE Nebrisi - International journal of molecular sciences, 2021 - mdpi.com
Parkinson's disease (PD) is a slowly progressive multisystem disorder affecting
dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized …

Toll-like receptors in the pathogenesis of neuroinflammation

V Kumar - Journal of Neuroimmunology, 2019 - Elsevier
Toll-like receptors (TLRs) are discovered as crucial pattern recognition receptors (PRRs)
involved in the recognition of pathogen-associated molecular patterns (PAMPs). Later …

The integration of inflammaging in age-related diseases

T Fulop, JM Witkowski, F Olivieri, A Larbi - Seminars in immunology, 2018 - Elsevier
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

I Pediaditakis, KR Kodella, DV Manatakis, CY Le… - Nature …, 2021 - nature.com
Parkinson's disease and related synucleinopathies are characterized by the abnormal
accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of …