Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

The efficiency, selectivity and sustainability benefits offered by enzymes are enticing
chemists to consider biocatalytic transformations to complement or even supplant more …

In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

Naturally occurring enzymes can be a source of unnatural reactivity that can be molded by
directed evolution to generate efficient biocatalysts with valuable activities. Owing to the lack …

The effective induction of high levels of stereocontrol for free-radical-mediated
transformations represents a notorious challenge in asymmetric catalysis. Herein, we …

Selective functionalization of aliphatic C–H bonds, ubiquitous in molecular structures, could
allow ready access to diverse chemical products. While enzymatic oxygenation of C–H …

Conspectus Catalytic reactions that construct carbon–nitrogen bonds are one of central
themes in both synthetic and medicinal chemistry since the obtainable nitrogen-containing …

Chiral amine diastereomers are ubiquitous in pharmaceuticals and agrochemicals, yet their
preparation often relies on low-efficiency multi-step synthesis. These valuable compounds …

The enantioconvergent C (sp3)–N cross-coupling of racemic alkyl halides with (hetero)
aromatic amines represents an ideal means to afford enantioenriched N-alkyl (hetero) …