Spinal cord stimulation: clinical efficacy and potential mechanisms

AD Sdrulla, Y Guan, SN Raja - Pain Practice, 2018 - Wiley Online Library
Spinal cord stimulation (SCS) is a minimally invasive therapy used for the treatment of
chronic neuropathic pain. SCS is a safe and effective alternative to medications such as …

Parameters of spinal cord stimulation and their role in electrical charge delivery: a review

JP Miller, S Eldabe, E Buchser, LM Johanek… - … : Technology at the …, 2016 - Elsevier
Objective All spinal cord stimulation (SCS) parameters (amplitude, pulse width, frequency)
influence the interaction of stimulation with the nervous system and impact the delivery of …

Long-term safety and efficacy of closed-loop spinal cord stimulation to treat chronic back and leg pain (Evoke): a double-blind, randomised, controlled trial

N Mekhail, RM Levy, TR Deer, L Kapural, S Li… - The Lancet …, 2020 - thelancet.com
Background Spinal cord stimulation has been an established treatment for chronic back and
leg pain for more than 50 years; however, outcomes are variable and unpredictable, and …

Comparison of 10-kHz high-frequency and traditional low-frequency spinal cord stimulation for the treatment of chronic back and leg pain: 24-month results from a …

L Kapural, C Yu, MW Doust, BE Gliner, R Vallejo… - …, 2016 - journals.lww.com
BACKGROUND: Pain relief with spinal cord stimulation (SCS) has focused historically on
paresthesias overlapping chronically painful areas. A higher level evidence supports the …

[HTML][HTML] Closed-loop neurostimulation: the clinical experience

FT Sun, MJ Morrell - Neurotherapeutics, 2014 - Elsevier
Neurostimulation is now an established therapy for the treatment of movement disorders,
pain, and epilepsy. While most neurostimulation systems available today provide stimulation …

Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action

J Caylor, R Reddy, S Yin, C Cui, M Huang… - Bioelectronic …, 2019 - Springer
Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers
an implantable, non-pharmacologic treatment for patients with intractable chronic pain …

Durability of clinical and quality-of-life outcomes of closed-loop spinal cord stimulation for chronic back and leg pain: a secondary analysis of the evoke randomized …

N Mekhail, RM Levy, TR Deer, L Kapural, S Li… - JAMA …, 2022 - jamanetwork.com
Importance Chronic pain is debilitating and profoundly affects health-related quality of life.
Spinal cord stimulation (SCS) is a well-established therapy for chronic pain; however, SCS …

Method and apparatus for controlling a neural stimulus

JL Parker, JH Laird, DM Karantonis… - US Patent …, 2016 - Google Patents
An implantable device applies and controls a neural stimulus. The device has a plurality of
electrodes, and a stimulus source for providing a stimulus to be delivered from the …

Absence of paresthesia during high-rate spinal cord stimulation reveals importance of synchrony for sensations evoked by electrical stimulation

B Sagalajev, T Zhang, N Abdollahi, N Yousefpour… - Neuron, 2024 - cell.com
Electrically activating mechanoreceptive afferents inhibits pain. However, paresthesia
evoked by spinal cord stimulation (SCS) at 40–60 Hz becomes uncomfortable at high pulse …

Spinal cord stimulation in chronic neuropathic pain: mechanisms of action, new locations, new paradigms

EA Joosten, G Franken - Pain, 2020 - journals.lww.com
Neuropathic pain is a complex, heterogeneous disorder that affects approximately 8% of the
total adult human population and comes with significant burden for both the patient and …