A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

In addition to the classical biological and biochemical framework, blood clots can also be
considered as active biomaterials composed of dynamically contracting platelets, nascent …

Essentials• Clot contraction influences the rate of fibrinolysis in vitro.• Internal fibrinolysis is
enhanced∼ 2‐fold in contracted vs. uncontracted blood clots.• External fibrinolysis is∼ 4 …

Deep vein thrombosis (DVT) is a common but unpredictable complication of surgical
interventions. To reveal an association between the blood clot contraction (retraction) and …

Thrombosis, resulting in occlusive blood clots, blocks blood flow to downstream organs and
causes life-threatening conditions such as heart attacks and strokes. The administration of …

Pulmonary thromboembolism (PTE) is part of a larger clinicopathological entity, venous
thromboembolism. It is also a complex, multifactorial disorder divided into four major disease …

Rheumatoid arthritis (RA) is an autoimmune disease associated with thrombotic
complications. To elucidate pathogenic mechanisms, hemostatic disorders in RA were …

Physiological processes such as blood clotting and wound healing as well as pathologies
such as fibroses and musculoskeletal contractures, all involve biological materials …

Blood clot contraction plays an important role in wound healing and hemostasis. Although
clot contraction is known to be driven by platelets, how single platelet forces relate to the …

Contraction of blood clots plays an important role in blood clotting, a natural process that
restores hemostasis and regulates thrombosis in the body. Upon injury, a chain of events …