Sex-related differences in oxidative stress and neurodegeneration

MA Tenkorang, B Snyder, RL Cunningham - Steroids, 2018 - Elsevier
Oxidative stress has been implicated in a number of neurodegenerative diseases spanning
various fields of research. Reactive oxygen species can be beneficial or harmful, depending …

Sildenafil for the treatment of Alzheimer's disease: A systematic review

O Sanders - Journal of Alzheimer's Disease Reports, 2020 - content.iospress.com
Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in
Alzheimer's disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is …

Alcalase-hydrolyzed oyster (Crassostrea rivularis) meat enhances antioxidant and aphrodisiac activities in normal male mice

Z Zhang, G Su, F Zhou, L Lin, X Liu, M Zhao - Food Research International, 2019 - Elsevier
The antioxidant and aphrodisiac properties of oyster meat (OM) and its hydrolysates by
alcalase (OMA) were compared. The results showed that OMA displayed a higher …

Withania somnifera ameliorates sexual arousal and impotence in stressed sexually sluggish male rats by modulating neurotransmitters and NO/cGMP/PDE5α …

A Yadav, RK Mishra - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Psychological stress is a growing global threat to male
sexual potency and erection efficiency. Withania somnifera (L.) Dunal (WS), also known as …

[HTML][HTML] Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats

AS Gouda, NA El-Nabarawy, SF Ibrahim - Toxicology reports, 2018 - Elsevier
Abstract Background Moringa oleifera extract (Lam) has many antioxidant and protective
properties. Objective: to investigate the antioxidant activities of Lam in counteracting the high …

Mimosa pudica Linn. extract improves aphrodisiac performance in diabetes-induced male Wister rats

C Palanichamy, D Nayak Ammunje… - Journal of …, 2023 - Taylor & Francis
Male sexual dysfunction is considered one of the major consequences of diabetes mellitus.
The medicinal plant, Mimosa pudica Linn. is believed to have numerous therapeutic effects …

Chitosan nanoparticles alleviated the adverse effects of sildenafil on the oxidative stress markers and antioxidant enzyme activities in rats

SA Sheweita, DME Alian, M Haroun… - Oxidative Medicine …, 2023 - Wiley Online Library
Sildenafil (SF) is widely used for erectile dysfunction and other conditions, though with
limitations regarding oral absorption and adverse effects. Despite nanotechnological …

Phosphodiesterase-5 inhibitors ameliorate structural kidney damage in a rat model of contrast-induced nephropathy

AM Iordache, AM Buga, D Albulescu, RC Vasile… - Food and Chemical …, 2020 - Elsevier
The aim of the study was to investigate the potential of sildenafil and tadalafil to ameliorate
structural kidney damage in contrast-induced nephropathy (CIN). A rat model of CIN was …

[HTML][HTML] Immunomodulatory, apoptotic and anti-proliferative potentials of sildenafil in Ehrlich ascites carcinoma murine model: In vivo and in silico insights

DS Morsi, IO Barnawi, HM Ibrahim, AM El-Morsy… - International …, 2023 - Elsevier
Sildenafil is a potent phosphodiesterase-5 (PDE5) inhibitor that effectively inhibits cGMP
and increases the strength of nitric oxide. PDE5 was overexpressed in several carcinomas …

Erectile dysfunction drugs altered the activities of antioxidant enzymes, oxidative stress and the protein expressions of some cytochrome P450 isozymes involved in …

SA Sheweita, AA Meftah, MS Sheweita, ME Balbaa - PLoS One, 2020 - journals.plos.org
Objectives Infertility is a global health problem with about 15 percent of couples involved.
About half of the cases of infertility are related to male-related factors. A major cause of …