How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

MB Goodman, P Sengupta - Genetics, 2019 - academic.oup.com
Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Microfluidics for understanding model organisms

N Frey, UM Sönmez, J Minden, P LeDuc - Nature communications, 2022 - nature.com
New microfluidic systems for whole organism analysis and experimentation are catalyzing
biological breakthroughs across many fields, from human health to fundamental biology …

[HTML][HTML] The nematode C. elegans senses airborne sound

AJ Iliff, C Wang, EA Ronan, AE Hake, Y Guo, X Li… - Neuron, 2021 - cell.com
Unlike olfaction, taste, touch, vision, and proprioception, which are widespread across
animal phyla, hearing is found only in vertebrates and some arthropods. The vast majority of …

Parallel processing of two mechanosensory modalities by a single neuron in C. elegans

L Tao, D Porto, Z Li, S Fechner, SA Lee, MB Goodman… - Developmental cell, 2019 - cell.com
Neurons convert synaptic or sensory inputs into cellular outputs. It is not well understood
how a single neuron senses, processes multiple stimuli, and generates distinct neuronal …

Surface acoustic waves enable rotational manipulation of Caenorhabditis elegans

J Zhang, S Yang, C Chen, JH Hartman, PH Huang… - Lab on a Chip, 2019 - pubs.rsc.org
Controllable, precise, and stable rotational manipulation of model organisms is valuable in
many biomedical, bioengineering, and biophysics applications. We present an …

[HTML][HTML] Ankyrin is an intracellular tether for TMC mechanotransduction channels

YQ Tang, SA Lee, M Rahman, SA Vanapalli, H Lu… - Neuron, 2020 - cell.com
Mechanotransduction channels have been proposed as force sensors in various
physiological processes, such as hearing and touch. In particular, TMC1 has been shown to …

Physically active bioreactors for tissue engineering applications

N Castro, S Ribeiro, MM Fernandes… - Advanced …, 2020 - Wiley Online Library
Tissue engineering (TE) is a strongly expanding research area. TE approaches require
biocompatible scaffolds, cells, and different applied stimuli, which altogether mimic the …

An afferent neuropeptide system transmits mechanosensory signals triggering sensitization and arousal in C. elegans

YL Chew, Y Tanizawa, Y Cho, B Zhao, JY Alex… - Neuron, 2018 - cell.com
Sensitization is a simple form of behavioral plasticity by which an initial stimulus, often
signaling danger, leads to increased responsiveness to subsequent stimuli. Cross-modal …

Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

J Zhang, JH Hartman, C Chen, S Yang, Q Li, Z Tian… - Lab on a Chip, 2020 - pubs.rsc.org
Effectively isolating and categorizing large quantities of Caenorhabditis elegans (C.
elegans) based on different phenotypes is important for most worm research, especially …

An expanded GCaMP reporter toolkit for functional imaging in Caenorhabditis elegans

J Ding, L Peng, S Moon, HJ Lee… - G3: Genes, Genomes …, 2023 - academic.oup.com
In living organisms, changes in calcium flux are integral to many different cellular functions
and are especially critical for the activity of neurons and myocytes. Genetically encoded …