Functional amyloids from bacterial biofilms–structural properties and interaction partners

Ü Akbey, M Andreasen - Chemical Science, 2022 - pubs.rsc.org
Protein aggregation and amyloid formation have historically been linked with various
diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids …

Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms

J Böhning, M Ghrayeb, C Pedebos, DK Abbas… - Nature …, 2022 - nature.com
Many bacteria in nature exist in multicellular communities termed biofilms, where cells are
embedded in an extracellular matrix that provides rigidity to the biofilm and protects cells …

Sticking to the subject: multifunctionality in microbial adhesins

PN Lipke, P Ragonis-Bachar - Journal of Fungi, 2023 - mdpi.com
Bacterial and fungal adhesins mediate microbial aggregation, biofilm formation, and
adhesion to host. We divide these proteins into two major classes: professional adhesins …

Multiscale X-ray study of Bacillus subtilis biofilms reveals interlinked structural hierarchy and elemental heterogeneity

DN Azulay, O Spaeker, M Ghrayeb… - Proceedings of the …, 2022 - National Acad Sciences
Biofilms are multicellular microbial communities that encase themselves in an extracellular
matrix (ECM) of secreted biopolymers and attach to surfaces and interfaces. Bacterial …

The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms

J Böhning, AK Tarafder, TAM Bharat - Biochemical Journal, 2024 - portlandpress.com
Numerous bacteria naturally occur within spatially organised, multicellular communities
called biofilms. Moreover, most bacterial infections proceed with biofilm formation, posing …

Molecular characterization of the N-terminal half of TasA during amyloid-like assembly and its contribution to Bacillus subtilis biofilm formation

J Cámara-Almirón, L Domínguez-García… - npj Biofilms and …, 2023 - nature.com
Biofilms are bacterial communities that result from a cell differentiation process leading to
the secretion of an extracellular matrix (ECM) by part of the population. In Bacillus subtilis …

Molecular architecture of the TasA biofilm scaffold in Bacillus subtilis

J Böhning, M Ghrayeb, C Pedebos, DK Abbas… - bioRxiv, 2022 - biorxiv.org
Many bacteria in nature exist in multicellular communities termed biofilms. Cells within
biofilms are embedded in a primarily self-secreted extracellular polymeric matrix that …

Beyond One-Trick Ponies: The Multifunctional Marvels of Microbial Functional Amyloids

M Landau - Microorganisms, 2023 - mdpi.com
Various organisms, including bacteria, protists, fungi, plants, and animals, secrete proteins
and peptides that self-assemble into ordered amyloid fibrils that perform different …

Molecular characterization of the N-terminal half of TasA during functional amyloid assembly and its contribution to Bacillus subtilis biofilm formation

J Cámara-Almirón, L Domínguez-García, NE Mammeri… - bioRxiv, 2023 - biorxiv.org
Biofilms are bacterial communities that result from a cell differentiation process that leads to
the secretion of an extracellular matrix (ECM) by part of the bacterial population. In Bacillus …

A Computational Characterization of Nanoscale Interactions of Biological Systems

C Luyet - 2024 - deepblue.lib.umich.edu
Treatment of biofilm infections is difficult, in part, due to the bacteria's pathogenicity and, in
part, due to biofilm's structural resilience. Not only does a drug have to traverse the …