[HTML][HTML] Systems biology approaches to investigate the role of granulomas in TB-HIV coinfection
A Hoerter, E Arnett, LS Schlesinger… - Frontiers in …, 2022 - frontiersin.org
The risk of active tuberculosis disease is 15-21 times higher in those coinfected with human
immunodeficiency virus-1 (HIV) compared to tuberculosis alone, and tuberculosis is the …
immunodeficiency virus-1 (HIV) compared to tuberculosis alone, and tuberculosis is the …
Single-Cell Transcriptomics of Mtb/HIV Co-Infection
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) co-infection continues to pose
a significant healthcare burden. HIV co-infection during TB predisposes the host to the …
a significant healthcare burden. HIV co-infection during TB predisposes the host to the …
Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts Mycobacterium tuberculosis Pathogenicity
Rationale: Different Mycobacterium tuberculosis (Mtb) strains exhibit variable degrees of
virulence in humans and animal models. Differing stress response strategies used by …
virulence in humans and animal models. Differing stress response strategies used by …
[HTML][HTML] System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection
Mycobacterium tuberculosis (Mtb) has developed specialized mechanisms to parasitize its
host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst …
host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst …
Host Immunity to Mycobacterium tuberculosis Infection Is Similar in Simian Immunodeficiency Virus (SIV)-Infected, Antiretroviral Therapy-Treated and SIV-Naive …
EC Larson, AL Ellis, MA Rodgers… - Infection and …, 2023 - Am Soc Microbiol
Pre-existing HIV infection increases tuberculosis (TB) risk in children. Antiretroviral therapy
(ART) reduces, but does not abolish, this risk in children with HIV. The immunologic …
(ART) reduces, but does not abolish, this risk in children with HIV. The immunologic …
[HTML][HTML] Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy
Abstract The expression of indoleamine 2, 3-dioxygenase (IDO), a robust
immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas …
immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas …
Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy
HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the
global public health. TB is the leading cause of death in HIV-infected persons, with one in …
global public health. TB is the leading cause of death in HIV-infected persons, with one in …
Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of Mycobacterium tuberculosis Infection in Macaques
M Gough, DK Singh, C Moodley, T Niu, NA Golden… - Pathogens, 2022 - mdpi.com
Despite a century of research into tuberculosis (TB), there is a dearth of reproducible, easily
quantifiable, biomarkers that can predict disease onset and differentiate between host …
quantifiable, biomarkers that can predict disease onset and differentiate between host …
[图书][B] Mycobacteria and the Macrophage
S Hingley-Wilson, SL Sampson, S Tiwari - 2023 - books.google.com
The macrophage (or “big eater”) is often considered the first cell type to encounter the
causative agent of Tuberculosis (TB), Mycobacterium tuberculosis, upon entry to the lung …
causative agent of Tuberculosis (TB), Mycobacterium tuberculosis, upon entry to the lung …
Prevention of TB in nonhuman primates by a stress-response deficient mutant of Mycobacterium tuberculosis via induction of classical T cell immunity
The need for novel vaccination strategies to control tuberculosis (TB) is underscored by the
limited and variable efficacy of the currently licensed vaccine, Bacillar Calmette-Guerin …
limited and variable efficacy of the currently licensed vaccine, Bacillar Calmette-Guerin …