Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …

The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

Interleukin‐17 (also known as interleukin‐17A) is a key cytokine that links T‐cell activation to
neutrophil mobilization and activation. As such, interleukin‐17 can mediate protective innate …

The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Critically ill post-surgical, post-trauma and/or septic patients are characterised by severe
inflammation. This immune response consists of both a pro-and an anti-inflammatory …

Multiple protein families, each with a distinct function, provide the traffic signals for
leukocytes. The selectin family of adhesion molecules (Figure 2) has an N-terminal domain …

PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

This standard-setting textbook has defined the field of immunology since 1984, and is now in
its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage …

What do cell adhesion, cell migration during embryogenesis, thrombosis, and lymphocyte
help and killing have in common? It has recently become clear that these ostensibly …