Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
Fungal morphogenesis, from the polarized growth of hyphae to complex reproduction and infection structures
Filamentous fungi constitute a large group of eukaryotic microorganisms that grow by
forming simple tube-like hyphae that are capable of differentiating into more-complex …
forming simple tube-like hyphae that are capable of differentiating into more-complex …
Regulation of fungal secondary metabolism
AA Brakhage - Nature Reviews Microbiology, 2013 - nature.com
Fungi produce a multitude of low-molecular-mass compounds known as secondary
metabolites, which have roles in a range of cellular processes such as transcription …
metabolites, which have roles in a range of cellular processes such as transcription …
Regulation and role of fungal secondary metabolites
J Macheleidt, DJ Mattern, J Fischer… - Annual review of …, 2016 - annualreviews.org
Fungi have the capability to produce a tremendous number of so-called secondary
metabolites, which possess a multitude of functions, eg, communication signals during …
metabolites, which possess a multitude of functions, eg, communication signals during …
Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change
Aflatoxins are toxic secondary metabolites produced by Aspergillus spp. found in staple food
and feed commodities worldwide. Aflatoxins are carcinogenic, teratogenic, and mutagenic …
and feed commodities worldwide. Aflatoxins are carcinogenic, teratogenic, and mutagenic …
Translating biosynthetic gene clusters into fungal armor and weaponry
NP Keller - Nature chemical biology, 2015 - nature.com
Filamentous fungi are renowned for the production of a diverse array of secondary
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …
How fungi defend themselves against microbial competitors and animal predators
M Künzler - PLoS Pathogens, 2018 - journals.plos.org
Filamentous fungi arrange their cells in linear, coenocytic arrays, referred to as hyphae, that
extend at their tips and are able to branch and fuse, leading to a loose, three-dimensional …
extend at their tips and are able to branch and fuse, leading to a loose, three-dimensional …
Aflatoxin biosynthesis: current frontiers
LV Roze, SY Hong, JE Linz - Annual review of food science and …, 2013 - annualreviews.org
Aflatoxins are among the principal mycotoxins that contaminate economically important food
and feed crops. Aflatoxin B1 is the most potent naturally occurring carcinogen known and is …
and feed crops. Aflatoxin B1 is the most potent naturally occurring carcinogen known and is …
Fungal evolution: cellular, genomic and metabolic complexity
MA Naranjo‐Ortiz, T Gabaldón - Biological Reviews, 2020 - Wiley Online Library
The question of how phenotypic and genomic complexity are inter‐related and how they are
shaped through evolution is a central question in biology that historically has been …
shaped through evolution is a central question in biology that historically has been …
Molecular mechanisms of Aspergillus flavus secondary metabolism and development
The plant and human opportunistic fungus Aspergillus flavus is recognized for the
production of the carcinogen aflatoxin. Although many reviews focus on the wealth of …
production of the carcinogen aflatoxin. Although many reviews focus on the wealth of …