Innate immune receptors in platelets and platelet-leukocyte interactions

PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Platelets and infection–an emerging role of platelets in viral infection

A Assinger - Frontiers in immunology, 2014 - frontiersin.org
Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis.
While platelet activation and elevated platelet counts (thrombocytosis) are associated with …

Platelet gene expression and function in patients with COVID-19

BK Manne, F Denorme, EA Middleton… - Blood, The Journal …, 2020 - ashpublications.org
There is an urgent need to understand the pathogenesis of coronavirus disease 2019
(COVID-19). In particular, thrombotic complications in patients with COVID-19 are common …

Proteomic and metabolomic characterization of COVID-19 patient sera

B Shen, X Yi, Y Sun, X Bi, J Du, C Zhang, S Quan… - Cell, 2020 - cell.com
Early detection and effective treatment of severe COVID-19 patients remain major
challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID …

Platelets in immune response to virus and immunopathology of viral infections

ED Hottz, FA Bozza, PT Bozza - Frontiers in medicine, 2018 - frontiersin.org
Platelets are essential effector cells in hemostasis. Aside from their role in coagulation,
platelets are now recognized as major inflammatory cells with key roles in the innate and …

Thrombocytopenia in virus infections

M Raadsen, J Du Toit, T Langerak… - Journal of clinical …, 2021 - mdpi.com
Thrombocytopenia, which signifies a low platelet count usually below 150× 109/L, is a
common finding following or during many viral infections. In clinical medicine, mild …

Role of platelets in detection and regulation of infection

I Portier, RA Campbell - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Platelets are classically known as essential mediators of hemostasis and thrombosis.
However, in recent years, platelets have gained recognition for their inflammatory functions …

Platelets: at the nexus of antimicrobial defence

MR Yeaman - Nature Reviews Microbiology, 2014 - nature.com
Platelets have traditionally been viewed as fragmentary mediators of coagulation. However,
recent molecular and cellular evidence suggests that they have multiple roles in host …

Patrolling the vascular borders: platelets in immunity to infection and cancer

F Gaertner, S Massberg - Nature Reviews Immunology, 2019 - nature.com
Platelets are small anucleate cellular fragments that are released by megakaryocytes and
safeguard vascular integrity through a process termed 'haemostasis'. However, platelets …

CXCR3 ligands in disease and therapy

K Van Raemdonck, PE Van den Steen… - Cytokine & growth factor …, 2015 - Elsevier
Chemokines, binding their various G protein-coupled receptors, lead the way for leukocytes
in health and inflammation. Yet chemokine receptor expression is not limited to leukocytes …