Regulation and functional role of the electron transport chain supercomplexes

S Cogliati, JL Cabrera-Alarcón… - Biochemical Society …, 2021 - portlandpress.com
Mitochondria are one of the most exhaustively investigated organelles in the cell and most
attention has been paid to the components of the mitochondrial electron transport chain …

Mitochondrial dysfunction is a key pathway that links saturated fat intake to the development and progression of NAFLD

RCR Meex, EE Blaak - Molecular nutrition & food research, 2021 - Wiley Online Library
Non‐Alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and is
characterized by fat accumulation in the liver. Hypercaloric diets generally increase hepatic …

Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis

JM Johnson, AD Peterlin, E Balderas, EG Sustarsic… - Science …, 2023 - science.org
Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which
brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner …

Altered mitochondrial metabolism in the insulin‐resistant heart

M Makrecka‐Kuka, E Liepinsh, AJ Murray… - Acta …, 2020 - Wiley Online Library
Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in
various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is …

The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function

ER Pennington, K Funai, DA Brown… - Biochimica et Biophysica …, 2019 - Elsevier
Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …

Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

A Pal, AE Al‐Shaer, W Guesdon, MJ Torres… - The FASEB …, 2020 - Wiley Online Library
Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE‐IT
trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here …

Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease

D Ristić-Medić, J Bajerska, VM Vučić - World Journal of …, 2022 - rimi.imi.bg.ac.rs
The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling
the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and …

Sex differences in pulmonary eicosanoids and specialized pro-resolving mediators in response to ozone exposure

MJ Yaeger, SW Reece, B Kilburg-Basnyat… - Toxicological …, 2021 - academic.oup.com
Ozone (O3) is a criteria air pollutant known to increase the morbidity and mortality of
cardiopulmonary diseases. This occurs through a pulmonary inflammatory response …

[HTML][HTML] Mechanisms by which dietary fatty acids regulate mitochondrial structure-function in health and disease

EM Sullivan, ER Pennington, WD Green, MA Beck… - Advances in …, 2018 - Elsevier
Mitochondria are the energy-producing organelles within a cell. Furthermore, mitochondria
have a role in maintaining cellular homeostasis and proper calcium concentrations, building …