Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis
and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and …

Bone is an outstanding, well-designed composite. It is constituted by a multi-level structure
wherein its properties and behavior are dependent on its composition and structural …

Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal
mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress …

The advent of COVID-19 has exposed digital and social inequalities across the world. The
United Nations (UN) and other global bodies like the International Monetary Fund (IMF) …

The lacunar-canalicular network (LCN) of bone contains osteocytes and their dendritic
extensions, which allow for intercellular communication, and are believed to serve as the …

While bone tissue is a hierarchically organized material, mathematical formulations of bone
remodeling are often defined on the level of a millimeter-sized representative volume …

This work addresses a number of fundamental questions regarding the topological
description of materials characterized by a highly porous three-dimensional structure with …

Osteoporosis, bone-muscle disuse, and long-term exposure to space microgravity cause
bone loss and promote bone fractures. Therapeutic devices and interventions for the …

Significant progress has been made to identify the cells and signaling molecules involved in
the mechanobiological regulation of bone remodeling. It is now well accepted that …

Motivated by the water layer-coated nanoscale bone mineral crystals and the elastoplastic
behavior seen at the extracellular scale, we develop a six-step hierarchical micromechanics …