The β-lactamases are the major bacterial defense of gram-negative bacteria against β-
lactam antibiotics. This review details the many types of β-lactamases, explains how they …

Objectives We performed a systematic review and meta-analysis to examine the impact of
extended-spectrum β-lactamase (ESBL) production on mortality and delay in effective …

Background. The effectiveness of piperacillin-tazobactam (PTZ) for the treatment of
extended-spectrum β-lactamase (ESBL) bacteremia is controversial. We compared 14-day …

The aim of this study was to evaluate the impact of carbapenem-resistant K. pneumoniae
bloodstream infections on mortality. During the study period 42, 68 and 120 patients were …

Bloodstream infections (BSI) caused by extended-spectrum β-lactamase (ESBL)-producing
organisms markedly increase the rates of treatment failure and death. We conducted a …

Background Individuals living with HIV/AIDS in sub-Saharan Africa generally take more than
90% of prescribed doses of antiretroviral therapy (ART). This number exceeds the levels of …

Background and objectives Bacteraemia caused by Enterobacteriaceae (EB) producing
extended-spectrum β-lactamase (ESBL+) has been associated with higher mortality …

Extended-spectrum β-lactamase (ESBL) producing gram-negative bacilli are a growing
concern in human medicine today. When producing these enzymes, organisms (mostly K …

Background. Timely identification of extended-spectrum β-lactamase (ESBL) bacteremia can
improve clinical outcomes while minimizing unnecessary use of broad-spectrum antibiotics …

Bloodstream infections caused by extended-spectrum-β-lactamase (ESBL)-producing
Klebsiella pneumoniae isolates are a major concern for clinicians, since they markedly …