Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum
Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can …

Obligate intracellular pathogens have coevolved with their host, leading to clever strategies
to access nutrients, to combat the host's immune response, and to establish a safe niche for …

Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild
and domestic animals and causing zoonotic infections in humans. T. gondii differs …

To survive and proliferate in diverse host environments with varying nutrient availability, the
obligate intracellular parasite Toxoplasma gondii reprograms its metabolism. We have …

Human onchocerciasis is a serious neglected tropical disease caused by the filarial
nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of …

Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular
parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity …

Abstract Background The apicomplexan parasite Toxoplasma gondii is cosmopolitan in
nature, largely as a result of its highly flexible life cycle. Felids are its only definitive hosts …

An effective metabolism is essential to all living organisms, including the important human
pathogen Staphylococcus aureus. To establish successful infection, S. aureus must …

Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and
unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction …

Abstract “In silico organisms” are computational genome-scale metabolic models used in
systems and synthetic biology developed by constraint-based metabolic simulations using …