Purpose: We previously reported that brief pulses of electrical stimulation (BPSs) can
terminate afterdischarges (ADs) during cortical stimulation. We investigated conditions …

Several new antiepileptic drugs (AEDs) have been introduced for clinical use recently.
These new AEDs, as did the classic AEDs, target multiple cellular sites both pre‐and …

Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that
arises at restricted brain sites and subsequently spreads to large portions of the brain …

The release of glutamate from astrocytes activates synchronous slow inward currents (SICs)
in hippocampal pyramidal neurons, which are mediated by the NMDA receptor and …

Purpose: Alterations in neuronal calcium (Ca2+) homeostasis are believed to play an
essential role in the generation and propagation of epileptiform events. Levetiracetam (LEV) …

Transient receptor potential vanilloid 1 (TRPV1) is a cation-permeable ion channel found in
the peripheral and central nervous systems. The membrane surface expression of TRPV1 is …

Abnormal involuntary movements and cognitive impairment represent the classical clinical
symptoms of Huntington's disease (HD). This genetic disorder involves degeneration of …

An important contributor to the generation of epileptiform activity is the synchronization of
burst firing in a group of neurons. The aim of this study was to investigate whether gap …

4‐Aminopyridine is a powerful convulsant that induces the release of neurotransmitters,
including glutamate. We report the effect of intrahippocampal administration of 4 …

This paper reports a novel neural probe technology for the manufacture of 3D arrays of
electrodes with integrated microchannels. This new technology is based on a silicon island …