The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

Autoimmune Polyendocrine Syndromes Autoimmune polyendocrine syndromes comprise a
diverse group of clinical entities involving functional impairment of multiple endocrine glands …

Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …

The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …

Cytokines mediate cell–cell communication in the immune system and represent important
therapeutic targets,–. A myriad of studies have highlighted their central role in immune …

Antigen-presenting cells (APCs) are master regulators of the immune response by directly
interacting with T cells to orchestrate distinct functional outcomes. Several types of …

Abstract Development of immunocompetent T cells in the thymus is required for effective
defence against all types of pathogens, including viruses, bacteria and fungi. To this end, T …

T cells undergo positive and negative selection in the thymic cortex and medulla,
respectively. A promiscuous expression of a wide array of self-antigens in the thymus is …

The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …

The spleen is the main filter for blood-borne pathogens and antigens, as well as a key organ
for iron metabolism and erythrocyte homeostasis. Also, immune and hematopoietic functions …