Many physiologic differences between children and adults may result in age-related
changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and …

The approach to paediatric drug dosing needs to be based on the physiological
characteristics of the child and the pharmacokinetic parameters of the drug. This review …

Malaria remains an important cause of illness and death in children and adults in countries
in which it is endemic. Malaria control requires an integrated approach including prevention …

The total number of paediatric formulations available only account for a small proportion of
the full therapeutic plethora required to effectively treat paediatrics and, therefore, the …

Background Clinical trials in children are being encouraged by regulatory authorities in light
of the immense off-label and unlicensed use of drugs in the paediatric population. The use …

The legacy of polychlorinated naphthalenes (PCNs) manufactured during the last century
continues to persist in the environment, food and humans. Metrological advances have …

Background and objective Clearance is an important pharmacokinetic concept for scaling
dosage, understanding the risks of drug-drug interactions and environmental risk …

Background: Children must be recognized as a sensitive population based on having
biological systems and organs in various stages of development. The processes of …

Providing safe and effective drug therapy to neonates requires knowledge of the impact of
development on the pharmacokinetics and pharmacodynamics of drugs. Although …

In children, the therapeutic benefits and potential risks associated with drug treatment may
be different from those in adults and will depend on the exposure, receptor sensitivity and …