Cardiac fibrosis is a common pathology in cardiovascular diseases which are reported as
the leading cause of death globally. In recent decades, accumulating evidence has shown …

Computational modelling of whole-heart function is a useful tool to study heart mechanics
and haemodynamics. Many existing heart models focus on electromechanical aspect …

Parameterised patient-specific models of the heart enable quantitative analysis of cardiac
function as well as estimation of regional stress and intrinsic tissue stiffness. However, the …

Progressive left ventricular (LV) growth and remodelling (G&R) is often induced by volume
and pressure overload, characterized by structural and functional adaptation through …

Simulations of cardiac electrophysiology and mechanics have been reported to be sensitive
to the microstructural anisotropy of the myocardium. Consequently, a personalized …

Impaired cardiac filling in response to increased passive myocardial stiffness contributes to
the pathophysiology of heart failure. By leveraging cardiac MRI data and ventricular …

Personalized computational cardiac models are considered to be a unique and powerful
tool in modern cardiology, integrating the knowledge of physiology, pathology and …

Pulmonary arterial hypertension (PAH) is a complex disease involving increased resistance
in the pulmonary arteries and subsequent right ventricular (RV) remodeling. Ventricular …

Personalised medicine is a relatively new area of healthcare that uses patient-specific data
at multiple scales, and different scientific models, to inform disease prognosis and treatment …