G-quadruplex DNA: a novel target for drug design
FY Teng, ZZ Jiang, M Guo, XZ Tan, F Chen… - Cellular and Molecular …, 2021 - Springer
Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
[HTML][HTML] DNA and RNA quadruplex-binding proteins
V Brázda, L Hároníková, JCC Liao, M Fojta - International journal of …, 2014 - mdpi.com
Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …
Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i …
G-Quadruplex: a regulator of gene expression and its chemical targeting
Summary G-quadruplex (G4) is an important type of nucleic acid secondary structure. An
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
abundance of potential G4-forming sites have been shown to exist in genomes, leading to …
A G-rich motif in the lncRNA braveheart interacts with a zinc-finger transcription factor to specify the cardiovascular lineage
Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate
gene expression; however, their mechanisms of action remain poorly understood. Here, we …
gene expression; however, their mechanisms of action remain poorly understood. Here, we …
Developing novel G-quadruplex ligands: From interaction with nucleic acids to interfering with nucleic acid–protein interaction
ZY Sun, XN Wang, SQ Cheng, XX Su, TM Ou - Molecules, 2019 - mdpi.com
G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …
genome. G-quadruplexes have been proved to be involved in the regulation of replication …
Human MYC G-quadruplex: From discovery to a cancer therapeutic target
W Wang, S Hu, Y Gu, Y Yan, DB Stovall, D Li… - Biochimica et Biophysica …, 2020 - Elsevier
Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …
The human CCHC-type zinc finger nucleic acid-binding protein binds G-rich elements in target mRNA coding sequences and promotes translation
The CCHC-type zinc finger nucleic acid-binding protein (CNBP/ZNF9) is conserved in
eukaryotes and is essential for embryonic development in mammals. It has been implicated …
eukaryotes and is essential for embryonic development in mammals. It has been implicated …
A Mechanosensor Mechanism Controls the G-Quadruplex/i-Motif Molecular Switch in the MYC Promoter NHE III1
MYC is overexpressed in many different cancer types and is an intensively studied
oncogene because of its contributions to tumorigenesis. The regulation of MYC is complex …
oncogene because of its contributions to tumorigenesis. The regulation of MYC is complex …
miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer
Carboplatin, administered as a single drug or in combination with paclitaxel, is the standard
chemotherapy treatment for patients with ovarian cancer (OVCA). Recent evidence suggests …
chemotherapy treatment for patients with ovarian cancer (OVCA). Recent evidence suggests …
Yeast transcription factor Msn2 binds to G4 DNA
DL Duy, N Kim - Nucleic Acids Research, 2023 - academic.oup.com
Sequences capable of forming quadruplex or G4 DNA are prevalent in the promoter regions.
The transformation from canonical to non-canonical secondary structure apparently …
The transformation from canonical to non-canonical secondary structure apparently …