To embrace the prospects of accurately diagnosing thousands of monogenic conditions,
predicting disease risks for complex traits or diseases, tailoring treatment to individuals' …

Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus
disease 2019 (COVID-19) positive cases with an extensive clinical information that were …

For small and isolated populations, the increased chance of mating between related
individuals can result in a substantial reduction in individual and population fitness. Despite …

Recessive alleles have been shown to directly affect both human Mendelian disease
phenotypes and complex traits. Pedigree studies also suggest that consanguinity results in …

Measuring inbreeding and its consequences on fitness is central for many areas in biology
including human genetics and the conservation of endangered species. However, there is …

Previous studies have hypothesized that autozygosity is decreasing over generational time.
However, these studies were limited to relatively small samples (n< 11,000) lacking in …

Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative
traits. We investigated associations between the fraction of the genome in runs of …

The children of related parents show increased risk of early mortality. The Native American
genome typically exhibits long stretches of homozygosity, and Latin Americans are highly …

Objectives Height is a complex, highly heritable polygenic trait subject to both genetic
composition and environmental influences. Recent studies suggest that a large proportion of …

The 14th African Society of Human Genetics (AfSHG) Morocco Meeting and 2nd
International Congress of the Moroccan Society of Genomics and Human Genetics …