Sepsis, a dysregulated host response to infection that causes life-threatening organ
dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

There is an ongoing threat of epidemic or pandemic diseases that could be caused by
influenza, Ebola or other emerging viruses. It will be difficult and costly to develop new drugs …

Despite significant progress in combating malaria in recent years the burden of severe
disease and death due to Plasmodium infections remains a global public health concern …

Background Plasmodium vivax is the most geographically widespread species among
human malaria parasites. Immunopathological studies have shown that platelets are an …

BACKGROUND Owing to increased spending on pharmaceuticals since 2010, discussions
about rising costs for the development of new medical technologies have been focused on …

Background Malaria in Brazil represents one of the highest percentages of Latin America
cases, where approximately 84% of infections are attributed to Plasmodium (P.) vivax …

Endothelial activation and microvascular dysfunction are key pathogenic processes in
severe malaria. We evaluated the early role of these processes in experimentally induced …

Plasmodium vivax is the major cause of human malaria in the Americas. How P. vivax
infection can lead to poor clinical outcomes, despite low peripheral parasitaemia, remains a …

Background Malaria remains a major public health concern with substantial morbidity and
mortality worldwide. In Malaysia, the emergence of Plasmodium knowlesi has led to a surge …