Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …

Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

The most widespread type of liver cancer, HCC, is associated with disabled cellular death
pathways. Despite therapeutic advancements, resistance to current systemic treatments …

The advent of immunotherapy has significantly reshaped the landscape of cancer treatment,
greatly enhancing therapeutic outcomes for multiple types of cancer. However, only a small …

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

Immunotherapy is an emerging antitumor modality with high specificity and persistence, but
its application for resected tumor treatment is impeded by the low availability of tumor …