Molecular farming–the slope of enlightenment

R Fischer, JF Buyel - Biotechnology advances, 2020 - Elsevier
Molecular farming can be defined as the use of plants to produce recombinant protein
products. The technology is now> 30 years old. The early promise of molecular farming was …

Plant-based biopharmaceutical engineering

L Eidenberger, B Kogelmann… - Nature Reviews …, 2023 - nature.com
Plants can be engineered to recombinantly produce high-quality proteins such as
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …

CRISPR/Cas9‐mediated knockout of six glycosyltransferase genes in Nicotiana benthamiana for the production of recombinant proteins lacking β‐1,2‐xylose and …

J Jansing, M Sack, SM Augustine… - Plant Biotechnology …, 2019 - Wiley Online Library
Plants offer fast, flexible and easily scalable alternative platforms for the production of
pharmaceutical proteins, but differences between plant and mammalian N‐linked glycans …

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

D Ghaderi, M Zhang, N Hurtado-Ziola… - Biotechnology and …, 2012 - Taylor & Francis
One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …

GoldenBraid: an iterative cloning system for standardized assembly of reusable genetic modules

A Sarrion-Perdigones, EE Falconi, SI Zandalinas… - PloS one, 2011 - journals.plos.org
Synthetic Biology requires efficient and versatile DNA assembly systems to facilitate the
building of new genetic modules/pathways from basic DNA parts in a standardized way …

Advances in plant molecular farming

OO Obembe, JO Popoola, S Leelavathi… - Biotechnology advances, 2011 - Elsevier
Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant

L Zeitlin, J Pettitt, C Scully… - Proceedings of the …, 2011 - National Acad Sciences
No countermeasures currently exist for the prevention or treatment of the severe sequelae of
Filovirus (such as Ebola virus; EBOV) infection. To overcome this limitation in our biodefense …

Role of N-Glycosylation in FcγRIIIa interaction with IgG

J Van Coillie, MA Schulz, AEH Bentlage… - Frontiers in …, 2022 - frontiersin.org
Immunoglobulins G (IgG) and their Fc gamma receptors (FcγRs) play important roles in our
immune system. The conserved N-glycan in the Fc region of IgG1 impacts interaction of IgG …

High level production of monoclonal antibodies using an optimized plant expression system

AG Diamos, JGL Hunter, MD Pardhe… - … in Bioengineering and …, 2020 - frontiersin.org
Biopharmaceuticals are a large and fast-growing sector of the total pharmaceutical market
with antibody-based therapeutics accounting for over 100 billion USD in sales yearly …

Plant molecular pharming for the treatment of chronic and infectious diseases

E Stoger, R Fischer, M Moloney… - Annual review of plant …, 2014 - annualreviews.org
Plant molecular pharming has emerged as a niche technology for the manufacture of
pharmaceutical products indicated for chronic and infectious diseases, particularly for …