Living in the liver: hepatic infections

U Protzer, MK Maini, PA Knolle - Nature Reviews Immunology, 2012 - nature.com
The liver has vital metabolic and clearance functions that involve the uptake of nutrients,
waste products and pathogens from the blood. In addition, its unique immunoregulatory …

[PDF][PDF] Reactivation of hepatitis B

JH Hoofnagle - Hepatology, 2009 - Wiley Online Library
Reactivation of hepatitis B refers to the abrupt increase in hepatitis B virus (HBV) replication
in a patient with inactive or resolved hepatitis B. Reactivation can occur spontaneously, but …

[HTML][HTML] Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: meta-analysis and examination of FDA safety reports

AM Evens, BD Jovanovic, YC Su, DW Raisch… - Annals of …, 2011 - Elsevier
Background Rituximab has been associated with hepatitis B virus reactivation (HBV-R).
However, the characteristics and scope of this association remain largely undefined …

[HTML][HTML] Liver immunology

DP Bogdanos, B Gao, ME Gershwin - Comprehensive Physiology, 2013 - ncbi.nlm.nih.gov
The liver is the largest organ in the body and is generally regarded by non-immunologists as
not having lymphoid function. However, such is far from accurate. This review highlights the …

Infectious complications of biological and small molecule targeted immunomodulatory therapies

JS Davis, D Ferreira, E Paige, C Gedye… - Clinical microbiology …, 2020 - Am Soc Microbiol
The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy

S Kusumoto, L Arcaini, X Hong, J Jin… - Blood, The Journal …, 2019 - ashpublications.org
Risk of hepatitis B virus (HBV) reactivation was assessed in B-cell non-Hodgkin lymphoma
(NHL) patients with resolved HBV infection (hepatitis B surface antigen negative, hepatitis B …

[HTML][HTML] Does rituximab increase the incidence of infectious complications? A narrative review

T Kelesidis, G Daikos, D Boumpas… - International Journal of …, 2011 - Elsevier
Background: Rituximab has increasingly been used for the treatment of hematological
malignancies and autoimmune diseases, and its efficacy and safety are well established …

Reactivation of hepatitis B virus following rituximab-based regimens: a serious complication in both HBsAg-positive and HBsAg-negative patients

SN Pei, CH Chen, CM Lee, MC Wang, MC Ma… - Annals of …, 2010 - Springer
Hepatitis B virus (HBV) reactivation is a well-known complication of lymphoma treatment in
the pre-rituximab era. This complication has not been as well studied, however, since …

Autoimmunity associated with immunotherapy of cancer

SM Amos, CPM Duong, JA Westwood… - Blood, The Journal …, 2011 - ashpublications.org
In this age of promise of new therapies for cancer, immunotherapy is emerging as an
exciting treatment option for patients. Vaccines and cytokines are being tested extensively in …

Risk of hepatitis B virus (HBV) reactivation in non-Hodgkin lymphoma patients receiving rituximab-chemotherapy: a meta-analysis

HJ Dong, LN Ni, GF Sheng, HL Song, JZ Xu… - Journal of Clinical …, 2013 - Elsevier
BACKGROUND: The addition of Rituximab to standard chemotherapy (C) has been reported
to improve the end of treatment outcome in non-Hodgkin lymphoma (NHL) patients …