An overview of spirooxindole as a promising scaffold for novel drug discovery

LM Zhou, RY Qu, GF Yang - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

[HTML][HTML] Synthesis of biologically active molecules through multicomponent reactions

D Insuasty, J Castillo, D Becerra, H Rojas, R Abonia - Molecules, 2020 - mdpi.com
Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

[HTML][HTML] Spirooxindole: a versatile biologically active heterocyclic scaffold

SS Panda, AS Girgis, MN Aziz, MS Bekheit - Molecules, 2023 - mdpi.com
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural
spirooxindole-containing compounds have been identified as bio-promising agents …

The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules

P Brandao, C Marques, AJ Burke, M Pineiro - European journal of …, 2021 - Elsevier
Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …

Synthetic strategies and pharmacological activities of chromene and its derivatives: An overview

MK Katiyar, GK Dhakad, S Arora, S Bhagat… - Journal of Molecular …, 2022 - Elsevier
Chromene is commonly found in nature and is considered one of the most frequently used
scaffolds in heterocyclic chemistry for the designing of chemical probes for therapeutic and …

Recent advances with alkaline phosphatase isoenzymes and their inhibitors

DM Zaher, MI El‐Gamal, HA Omar… - Archiv der …, 2020 - Wiley Online Library
Alkaline phosphatases are found in different living species and play crucial roles in various
significant functions, such as hydrolyzing a variable spectrum of phosphate‐containing …

Anticancer potential of spirocompounds in medicinal chemistry: A pentennial expedition

D Bora, A Kaushal, N Shankaraiah - European Journal of Medicinal …, 2021 - Elsevier
Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

Engaging isatins in multicomponent reactions (MCRs)–easy access to structural diversity

P Brandão, CS Marques, EP Carreiro… - The Chemical …, 2021 - Wiley Online Library
Multicomponent reactions (MCRs) are a valuable tool in diversity‐oriented synthesis. Its
application to privileged structures is gaining relevance in the fields of organic and …

Synthesis, characterization of phyto-functionalized CuO nano photocatalysts for mitigation of textile dyes in waste water purification, antioxidant, anti-inflammatory and …

KM Navada, N G. K, JN D'Souza, S Kouser, M D. J - Applied Nanoscience, 2021 - Springer
In this scientific paper we report, cost-effective synthesis of unique copper oxide
nanoparticles (CPC NPs) coupled with properties from phytocompounds of Pouteria …

Steering the antitumor drug discovery campaign towards structurally diverse indolines

A Thakur, A Singh, N Kaur, R Ojha, K Nepali - Bioorganic Chemistry, 2020 - Elsevier
Indoline framework is often perpended as a privileged heterocycle present in medicinally
valuable compounds of natural and synthetic origin. This review article presents the rational …