Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

In recent years, there have been many studies on the function of nitric oxide synthase (NOS)
in experimental animals and humans. This review analyzes and explores the relationship …

Allergic asthma is associated with airway inflammation and airway hyperresponsiveness.
Macrophage polarization has been shown to have a profound impact on asthma …

Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …

Obesity and resistance to insulin are closely associated with the development of low-grade
inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its …

In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in
modulating the outcome of infections and autoimmune diseases as well as the underlying …

The CCL2 chemokine mediates monocyte egress from bone marrow and recruitment into
inflamed tissues through interaction with the CCR2 chemokine receptor, and its expression …

Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct
pathological stages. Fundamental to ARDS is the acute onset of lung inflammation as a part …

Resident and recruited macrophages are key players in the homeostatic function of the liver
and in its response to tissue damage. In response to environmental signals, macrophages …

Macrophages are key regulators of many organ systems, including innate and adaptive
immunity, systemic metabolism, hematopoiesis, vasculogenesis, malignancy, and …